11 March 2023

Branded Versus Generic Medicines in India.My Experience of 2022

Post First Written & Published From New Delhi India on 11-March-2023 @ 19:00 Hrs IST (GMT + 0530 Hrs) Saturday. 


Those who want my verdict, advice, opinion whether to use Generic Medicines, it's Quality after multiple raids on Indian Generic Manufacturing Companies in April 2023, please read this post from the end & skipp the beginning.
 
If you need the PDF e-Book Bottle of Lies by Katherin Eban on the corruption,bad quality of Indian Generic Medicines after the collapse off Ranbaxy Labs please send e-mail

E-Mail  preferred. Send e-mail if you need the latest updated post in PDF.

 
This answer is written as per the experience of end user in New Delhi India. May not be relevant world wide. 
 
Abbreviations Used:- 
 
G/N:Generic Name of the Medicine,B/N: Brand Name of the Medicine.  
 
Brake Cylinder and Brake Pipe Feed Pressure is Human Body Blood Pressure which ranges from 120/80 to 140/90 mm/Hg depending upon age of a person.

BPPI is Bureau of Pharma Public Sector Undertakings of India, PMBI is Pharmaceutical Medical Devices Bureau of India both having Head Quarters,Videocon Tower,Jhandewalan Rani Jhansi Road, New Delhi-110055,selling Pure generic versions of bulk formulations on Rx Name. 

PMBJAUSHK is Pradhan Mantri Bhartiya Jan Aushadhi Kendra selling lesser known branded generics, pure generics medicines at 60 to 80% discount on MRP.

B=Branded The original inventor, innovator of a drug formulation, protected by products patents, usually, a outside India, registered pharma company like Abbott labs,Alcon, Novartis AG, Sanofi, Pfizer, Bayer-Corporation, GSK-UK, J&J, Astra-Zeneca, Roche, Boehringer Ingelheim,e-Merck but may operate in India via wholly owned subsidiaries to market their patented formulations.
 
G/N:Amlodipine Besilate for treatment of hypertension, high blood pressure was innovated, formulated by Pfizer Inc USA patented in 1982 sold as B/N:Amlogard® in India by Pfizer as on 03/2023. 
 
G/N: Sildenafil for treatment of male erectile dysfunctional B/N: Viagra® by Pfizer Inc, product patented in 1998 till 2020.

Most eye drops & intra occular lenses needed before,after, during Cataract eye surgery are made by (Alcon) outside India imported in India by Alcon India. 

Accuchek instant blood glucose, test machine strips by Roche,G/N:Sorafenib B/N:Nexavar by Bayer corporation germany, for liver, kidney, thyroid cancer treatment are examples.
 
P/B=Doctor Prescribed Branded, lower priced, reverse engineered versions, of original patented medicines,called Generics, made after expiry of Rights, Patents, of the Original Formulation, made or marketed or both by a single or different companies.
 
Aristo Pharma, Aurobindo, Alembic, Alkem, Anglo-French Drugs & Industries, Biocon, Biological-E, Dr Reddy’s Labs, Cadila, Cipla, Duke Lab, Eris Life Sciences, FDC, Franco Indian, Glenmark, Geno, IPCA Labs, Intas,J.B Chemical Pharma, Lupin, Mankind,Medley, MacLeods, Microlabs, Raptakos Brett, Sun Pharma, Systopic Labs, TTK Pharma,Wockhardt, Zydus are some examples. Almost all companies are listed on the Indian Equity Stock Exchanges.

Brand Dolo-650® by micro labs, Amtas, by Intas Pharma, Nebicard by Torrent Pharma are examples.

B/G=Lesser known Branded Generics i.e a much cheaper version of P/B also termed as ethical branded medicine. 
 
Elder Pharma, Leeford health, Aishwarya Healthcare, Knoll® healthcare, SAG neuro-sciences, Vellent healthcare, kyrocare,Sentosa GEiGY (India) Labs Ltd are B/G companies. 
 
Levetam-500 of Aishwarya, Citicoz-NS Plus, Lacosiez of SAG Neurosciences, Levetram-500 of Sentosa are Brands of these Companies.

P/G-Pure generic medicine sold by BPPI + PMBI only on it's Rx generic salt,api molecule formulation, strength name via PMBJAUSHK

Example paracetamol 500, ciprofloxacin 500.

M.R.P maximum retail price inclusive of 12 or 18% GST above which a medicine cannot be sold. But can be sold much below M.R.P. 
 
₹=Indian currency Rupee symbol. 1*US $ equals 82.54 on 18-03-2023
 
All Dates in British DD/MM/YYYY Format. Read the above abbreviations multiple times before proceeding further

I'm writing this after observing the reactions, efficacy, of doctor prescribed branded generics (P/B),Branded generics (B/G),Pure generics (P/G) on a brain stroke, right side paralysis, male patient aged 77+ who was discharged from Sir Ganga Ram Hospital (SGRH),Old Rajinder Nagar,New Delhi in middle off July 2022 for further recovery at home.

The prescribed branded medicines on hospital discharge were:- 
  • Strocit®Plus, For damaged brain cell repair, after stroke.
  • Epilive®500,To prevent seizures
  • Lacoset-50, To reduce side effect,dosage of Epilive®500 + prevent seizures.
  • Lipirose®-F10. To reduce blood lipids & prevent future stroke.
All 4 affordable,but branded generics in PMBJAUSHK costed 60% less. For 1st 3 months, I used only the brands prescribed to aid the brain's neuroplasticity,ie faster recovery.

Later when dosage was doubled, w.e.f 21-10-2022, I tried Less Known B/G Citinol-PR, Citicoz NS Plus, Levetram-500, Lacosiez-50, Levetam-500, Rosuvat-F, and they were equally effective at less cost. 
 
As off 11–March–2023, Prescribed Branded Medicines, 

Strocit®Plus (Generic Name:Citicoline Sodium 500 mgs + Piracetam 800 mgs) by Sun Pharma costs MRP ₹ 800/10 Tabs.
 
Lacoset-50 (GN:Lacosamide)by Sun Pharma, MRP ₹ 92/10 Tablets.

 Epilive®500 (GN:Levetiracetam) by Lupin MRP ₹ 220/15 Tabs,
 
Lipirose®-F10 (GN: Rosuvastatin 10 mgs + Fenofibrate 145mgs) by Mankind  Pharma,MRP ₹ 190/10 Tabs.

In general, all central delhi, brick & mortar medical stores offer 15% cash, PayTM/ PhonePe,UPI discount. here in after all P/B prices will be mentioned net of this discount with MRP in brackets.

Whereas,in PMBJAUSHK, B/G, 

  • Citinol-PR costs ₹ 290/10 Tabs (MRP ₹ 830) Knoll® Healthcare
  • Citicoz NS Plus ₹ 280/10 Tabs (MRP ₹ 665) SAG NeuroSciences Pvt Ltd
  • Levetram-500-₹ 80/10 Tabs (MRP ₹ 147) Sentosa GEiGY India Labs Ltd
  • Lacosiez-50 ₹ 45/10 Tabs (MRP ₹ 95) SAG Neurosciences pvt ltd
  • Rosuvat-F ₹ 55/10 Tabs (MRP ₹ 225) Aishwarya healthcare

If pure generics of the above 5 made, is available, it costs only ₹ 220/10 Tabs,₹ 68/10,₹ 28/10, ₹ 34/10.

Cost Savings Example:1 

P/B 1) Strocit®Plus, 2) Epilive®500, 3)Lacoset-50, 4) Lipirose®F10, costs ₹ 680/10 Tabs, ₹ 125/10, ₹ 78.20/10, ₹ 162/10 in open market.

If 2 Tabs each, are prescribed in a day, then total cost is (₹136.00+25.00+15.64+32.40)=₹ 209.04*90 Days=₹ 18,814/-. 

Cost Savings Example:2 

If all 4 substituted with lesser known B/G i.e Citicoz NS Plus, Levetram-500, Lacosiez-50, Rosuvat-F, then cost is (₹ 56.00+ 16.00+ 9.00+ 11.00=₹ 92/ per day*90 days)=₹ 8,280/-for 90 days.

A net saving off ₹ 18,814 (-) 8,280=₹ 10,534/90 days or 56% between open market, prescribed branded. 

Cost Savings Example 3. 

If all 4 are substituted with P/G then cost is (₹ 44.00+13.60+5.60+6.80=₹ 70*90 Days 6,300/-.

Net Savings off ₹ 18,814 (-) 6,300=₹12,514/- or 66.51% over open market, P/B & ₹ 8,280/- (-) 6,300/-=₹ 1,980/- over B/G.

P/B, Rabeprazole 20 mgs (Rabekind ₹ 66/15). Pantoprazole 40mgs (Pantop-40, PAN-40) costs ₹ 130/10 & ₹ 155/15 Tabs.  P/G ₹ 11/10 Tabs & ₹ 8/10 Tabs B/G Panpazole 40 of Aishwarya Healhcare 40/15 Tabs(M.R.P 169/15).

See the Difference in costs between Simple Proton Pump Inhibitors.

So to maintain cost + pharma efficacy, I rotated between the three. My father is recovering gradually. All his neurological tests, eeg, nccv,emg,mri brain screening, blood tests, lft, cbc, serum homocysteine, lipid profile are better than normal, after using low cost branded generics + pure generics. 

Cost Savings Example:—4. 

My 77+ mother for her B.P control is taking pure generics, similar to prescribed branded medicines, Amtas 5 mgs (G/N:Amlodipine) made by Intas pharma,Nebicard-5 mgs (G/N:Nebivolol) by Torrent Pharma written by Dr Romeo Mike, Senior Consultant, Director Non Invasive, Heart, SGRH,New Delhi.

One Tablet of Amtas 5 mgs (Intas 64/30) & 1 Tab of Nebicard 5 mgs  (₹146/10) a day, cost ₹ 2.13+14.60=₹ 16.73/day. ₹ 16.73*30=₹ 502/-

P/G costs ₹ 0.50+4.00=₹ 4.50 per day.₹ 4.50*30=135/-

B/G Nebivol 5 & Amlodip 5 off Knoll & Aishwarya Healthcare costs ₹45/10 & ₹10/10 Tabs. Per Month Cost ₹ 165/-.



 

Amlodipine Besilate was the Original Branded Molecule Discovered, Patented Formulation of Amlodipine by Pfizer Inc is available as Amlogard®5 mgs,priced at ₹ 92/30 Tabs M.R.P. It was first launched in 1982.


 

Another new generation modern branded drug B.P Reducer LN Bloc 5 mgs by Eris life sciences pvt ltd (GN:-Cilnidipine 5 Mgs) costs ₹ 55/10 Tabs(M.R.P 96.62/15 Tabs Pack).The same by Lupin Ltd as DILNIP-5 costs 109.50/30 Tabs MRP. Amlodipine 5 mgs by Lupin Ltd as Lupidip 5 costs 22.26/10 Tabs.

Whereas B/G Clindinol-5 mgs by Knoll™ Healthcare Pvt Ltd,  costs ₹ 25/10 (MRP ₹78/10) & P/G ₹ 11/10 Tabs.

The most popular Cilnidpine Brand CILACAR® costs ₹ 70.73 for 5 Mgs*10 Tablets M.R.P made by J.B Chemicals Pharmaceuticals Ltd Ankleshwar Gujarat.



Cost Savings Example:—5 Imported Branded, Vs BG Vs PG for Pre & Post Cataract Eye Surgery. 

A 5 ml Vigamox™ eye lotion (Generic Name:-Moxifloxacin) & 5 ml Nevanac™ eye lotion (GN:Nepafenac 1 mg) branded made by Alcon Labs,fortworth texas,USA costs ₹ 357 & ₹ 351 after importing in India.

Systane™Ultra lubricant eye drops ₹ 494/10ml GN: Polyethylene Glycol 400+ Propylene Glycol.Genteal 10ml lubricant eye drops ₹ 219,Alcon,Made in Singapore, fully imported.

P/B,Cipla made, Moxicip (Moxifloxacin) costs ₹ 208.00,PB Sun Pharma made Milflox ₹ 180.00. PMBI made for PMBJAUSHK (GN: Moxifloxacin) ₹14.30/5ml.

B/G Nepcinac Eye Drop by Cipla costs ₹ 194/— equivalent of Nevanac. PMBI made for PMBJAUSHK Nepafenac costs ₹ 66/5 ml. 

A Simple Lubricant Eye Drops of Carboxy methyl cellulose, Boric Acid,Glycerin P/B Cipla's Add Tears,M.R.P ₹135/10ml in Open Market. 

B/G Eye Refresh Drops by Elder Pharma is ₹60 (MRP ₹ 156). P/G of PMBI ₹24/10ml. Both available in PMBJAUSHK.

But a rule of thumb, as Eye, is a very delicate, sensitive part, Eye surgeon's recommend only branded Alcon imported than BG, Made in India. They 'll never recommend pure generics off BPPI+PMBI.

Cost Savings Example:—6 

Bayer Corporation's GN:Sorafenib Brand: Nexavar for treatment of Liver+Kidney+Thyroid Cancer costed $ 5,600/— per month in 2012, whereas BG NATCO Pharma in India made it available for $ 175/month after winning the patents case in Indian courts.

As on 18–03–2023, B/G Soranib Tablet 200 mgs by Cipla costs ₹ 2,276/30 Tabs MRP, available at ₹1,593/30 online after 30% discount. Sorafenate 200 mgs by NATCO Pharma,₹7,692/120 tabs final online price.

Bayer Corporation's imported branded Nexavar costs ₹ 1,34,355/- for 60 Tablets online.  

The above was repeated in India with Novartis AG Switzerland's Blood cancer (Leukaemia) branded innovated drug Glivec®400 (Generic Name: Imatinib Mesylate) in 2012. Branded Generic Versions are made in India by Cipla as Imatib-400 for ₹ 1,190/30 Tabs and Pure Generic by PMBI at ₹ 350/10 Tabs.  

Original Branded, Formuated, Patented, Imported Glivec®400 mgs of Novartis AG Stein Switzerland has M.R.P of 7,140/30 Tablets but available online for 2,400/30 Tabs.  

glivec®400 is a perfect example of original, discovered, formulated, innovated, product patented, branded Medicine. If Novartis starts local manufacturing of glivec®400 within India, even then it will be termed as original branded medicine as Novartis AG is the inventor of this. Refer image below.
 
All other versions are low cost Branded Generics or Pure Generics.
 



The above example applies to Novartis AG, Patented Formulation,Vymada®100 mgs (Generic Name: Sacubitril+Valsartan) to improve Weak Heart Pumping, prevent heart failure, which was Product Patented Till 31-Jan-2023,costed  1,200/14 Tablets via imports,after that Generic Versions are available in India. As On 06-06-2023 Vymada®100 costs  660/14 Tablets. Indian Generic Version, by Intas Pharma, Arney-100 costs  419/14 Tabs M.R.P.
 

Cost Savings Example:—7 

Branded Original Innovated, Made in India Versus BG Versus PG.

GN:-Fexofenadine Hydrochloride Tabs IP 120mg An anti allergic.

Branded Allegra-120 mgs by Sanofi India costs ₹ 219/10 Tabs, B/G AIR120 by Systopic Labs ₹ 49/10 Tabs. P/G ₹ 22/10 Tabs.All prices M.R.P  

Now in examples 5-7 we can see the huge cost difference between branded imported alcon, bayer corporation, novartis-ag, sanofi India & B/G Cipla, Sun Pharma, NATCO, Systopic, Pure Generics.

This applies to all Branded versus B/G versus P/G in India.

Old Generation Formulations for Enlarged Prostate Treatment (BPH) without Surgery.

Pure generics, tamsulosin hydrochloride prolonged release 0.40 mgs by PMBI, costs ₹ 20/10 caps.

B/G, Temsunir 0.40 mgs,₹ 40/10 (Aishwarya) MRP ₹ 93/10.

P/B,Tamgress™,by La Renon Healthcare Private Ltd costs ₹ 95/10 in Open Market.

All 3, same formulations, for enlarged prostate treatment without surgery. In Medical terms, Benign Prostatic Hyperplasia.

Modern New Generation Formulations for Enlarged Prostate Treatment (BPH) without Surgery.

B/G, Silodolix-D (GN:Silodosin 8 mgs + Dutasteride 0.50 mgs) by Kyracare Pharma ₹ 174/10 (MRP ₹ 430).

PMBI made P/G ₹ 140/10.B/G Daxaflow 8D also cost the same. 

Whereas Urologist Doctor P/B Rapilif ® D8 by IPCA Labs, costs ₹ 388/10 in open market(M.R.P 456/10 Caps)



 

All 3, advanced formulations, over Tamsulosin 0.40 mgs for enlarged prostate treatment without surgery i.e Benign Prostatic Hyperplasia.

Cost Savings Example:—8

In 3*10 strip carton,of Lipirose®-F10,₹ 162/10 (MRP ₹ 199/10)marketed by Mankind Pharma Ltd, Okhla Industrial Estate-3, New Delhi-110020, but is manufactured by Ravenbhel Biotech, Epip, Sidco, Kartholi, Bari Brahmana, Jammu-181133.



 

Citicoz-NS Plus & Lacosiez-50 marketed by SAG Neurosciences Pvt Ltd New Delhi is MFD by Logos Pharma & Algen Healthcare Ltd in similar villages of Himachal Pradesh India.

 

 



 

 



 

B/G Rozutin-F marketed by Knoll Healthcare Pvt Ltd,made by VIP Pharma Pvt Ltd, Village Manpura Tehsil Nalagarh, District Solan, Himachal Pradesh-174101. 

Net Price ₹ 60/10 Tablets (MRP271/10). Available Online for ₹ 216/10 Tabs as on 11-04-2023.

B/G Rosuvat-F by Aishwarya Healthcare is made by Aishwarya Celebrity Bio Pharma Pvt Ltd in similar villages of Himachal Pradesh,India.

Net Price ₹ 55/10 Tabs (MRP ₹ 225/10)    


 

BPPI P/G Rosuvastatin & FenoFibrate Tablets I.P (10mg+160mg) is Mfd by:Theon Pharma Ltd,Village Saini Majra, Tehsil Nalagarh,District Solan(H.P) Himachal Pradesh-174101.





Net Price ₹ 31/10 Tabs. 

Another,Statin Class, Rosubest F marketed by Cadila Pharma Ltd Ahmedabad India is made by PMBI Contract Maker Theon Pharma but M.R.P ₹ 199/10 Tabs. 
 
Both same Salt Composition as PMBI Drug Code 435 as above. Refer images below.
 


 
 
Sun Pharma's Rosuvas F10 (Rosuvastatin 10mgs+160mg Fenofibrate) costs ₹ 387/15 Tablets M.R.P made in it's own Sikkim Facility.

See the Price differences between same, mild difference formulations in Statins.

So B/G + P/G sold via PMBJAUSHK work. There is no doubt about this. But @60% discount over P/B open market.

  How Online+Open Market Pharma Stores make a killing by exploiting the Ignorance of Buyers.

Silodolix-D if sold online or in open market by medical shops, buying from distributors,after 15% discount will cost ₹ 366/-.

This applies to brain repair stroke medicines, Citnol-PR (MRP 830)Citicoz NS Plus (MRP 665)

Citinol-PR which costs 290-365/10 Tabs in PMBJAUSHK is being sold at ₹ 414/10 Tabs on TrueMeds On 18-04-2023. 



 

How I saved myself getting conned due to correct medical knowledge. 

The, neuro surgeon, treating my father in October-2022 prescribed Cirrosam-400 tablets (Generic Name:S-Adenosyl-L-Methionine.In short SAM-e. By La Renon Healthcare Private Ltd) one tablet daily for one month. This costs ₹1,100/10 tabs with nil discount in open market.



There is no, low cost, substitute brand available, nor any pure generic version.This medicine is prescribed only for fatty liver, cirrhosis patients, which my father didn't have, as he, has never done alcohol, even once in his life.

In Nov 2022, my Father's LFT test report (asked for by the doctor) was better than normal.

This type of medication is termed as Propaganda Generics, where the benefit of a medicine, doesn't justify, it's high cost. From pharma maker> distributor> stockist> retailer> MR>doctor all involved in making money @ the cost off patient. In reality cost of one tablet Cirrosam-400 could be just ₹ 10.00

Another aspect, US-FDA Inspectors, during 26–04–2022 to 09–05–2022, in, Halol Gujarat found certain ineffective, unclean, unhygienic, dusty environment, improper vessels, low quality equipment, used in manufacturing processes, by Sun Pharma Industries hence stopped imports to USA, from Halol Gujarat Plant, unless Sun Pharma took, addressed their concerns, seriously in December-2022.

In Feb 2023 Sun Pharma recalled 34K Bottles of Branded Generic Drug Diltiazem Hydrochloride ER Capsules used to treat High BP, Angina, Irregular Heartbeat after Failing in Dissolution Testing. These were made, exported by Sun Pharma from Halol, Gujarat India to USA. 

Above Source:-CNBC TV18 & Money Control.   

Fortunately Strocit®Plus, Lacoset-50 are manufactured by Sun Pharma Labs in India at Sikkim.



In 2022-2023 Lupin Ltd Inc USA had multiple run-in's with the US-FDA & had to recall multiple products from the US Market after Failing Quality Tests.

In Feb 2023 The Indian drug-maker Lupin Limited recalled 5,720 tubes of a skin medicine over quality issues, according to US Food and Drug Administration (FDA).

 The Lupin's US arm Lupin Pharmaceuticals Inc is recalling the tubes of Clobetasol propionate Cream from the US market. The medicine is being recalled after the US FDA found it to be of poor quality. The cream is used in the treatment of various skin conditions, such as dermatitis, eczema, and psoriasis.

The tubes being recalled were manufactured at Lupin's Pithampur plant in Madhya Pradesh. The formal reason for the recall is the following finding by the FDA: "subpotent Drug: Low assay result observed during long-term stability testing".

 Lupin initiated the Class III nationwide (US) recall of the affected lot on January 23 this year. As per the FDA, a class III recall is initiated in a "situation in which use of, or exposure to, a violative product is not likely to cause adverse health consequences"

 In January 2023, Lupin recalled 16,056 bottles of Rifampin Capsules used in the treatment of all forms of tuberculosis. The recall was observed after impurities were detected and the drug failed stability test.

 In December 2022, Lupin recalled blood pressure medicine Quinapril over impurities in the tablets. The prolonged use of the impurity detected can cause cancer, WebMD quoted FDA as saying. The Hill reported, "The tablets were contaminated by substances known as nitrosamines, which the FDA reports are commonly found in food and water.These impurities are found in meats, dairy products and vegetables, and can increase a person’s risk of developing cancer when faced with prolonged exposure, according to the FDA."

 In September 2022, Lupin recalled 7,872 bottles of same Rifampin Capsules which were also recalled last month. The recall was for manufacturing lapses.

 In January 2022, Lupin recalled 50,832 bottles of anti-bacterial medicine Gatifloxacin Ophthalmic Solution. It's used in eye treatment. The recall was ordered after failing stability tests.

 In January 2022, it was also reported that Lupin was recalling 23,965 bottles of Oxycodone Hydrochloride tablets. The tablets are used for the treatment of moderate to severe pain.

 

So, it is not true, that prescribed branded medicines, are 100% safe in India, just because they have high cost, are recommended, written by successful doctors.

Now the most shocking truth of Prescribed Branded Medicine Manufacturing which I learnt after seeing the Carton of Nebistar®5, Lupidip-5,Dilnip-5,Citistar-PM all Doctor Prescribed Brands, by Lupin Ltd. 




 


 



Here Lupin is only a marketing Company whereas, Nebistar®5 & Dilnip-5 Tablets are made by Hetero Labs Ltd-Unit II, Village Kalyanpur Chakkan Road, Tehsil Baddi, District Solan, Himachal Pradesh-173205,India.

Citistar PM is made by Synokem Pharma Ltd at Ranipur(BHEL) Haridwar-249409. 

Epilive®500,is made by Lupin Ltd in Barhi Brahmana in it's Own Manufacturing Facilities Jammu like Ravenbhel Biotech makes Lipirose®-F10 for Mankind Pharma. 

Lupidip-5 Tablets are made by The Madras Pharmaceuticals_Co_Ltd Old Mahabalipuram Road, Kanapakkam, Chennai-600095, Tamil-Nadu India. 

Now I have no Quality issues with Lupidip-5 made by The Madras Pharmaceuticals Ltd for Lupin. But what about Hetero Labs-2,Synokem Pharma in Himachal Pradesh & Haridwar India?

So what is the difference between Doctor Prescribed Branded, Dilnip-5, Nebistar®-5, (Vs) Low priced, branded generics, PMBI pure generics,if all are made,in some remote H.P/J.K/Uttarakhand Village, ?

Does Lupin Ltd have the authority, power, to enforce, strict, regular quality checks, controls, over Hetero ?

On 27-03-2023 I got Pure Generic Levetiracetam I.P 500mgs of PMBI from PMBJAUSHK. Upon scrutiny the manufacturer was Pure & Cure healthcare private ltd (PCHPL) Haridwar Uttarakhand, a subsidiary of Akum drugs & pharma ltd a reputed contract pharma maker company based in New Delhi.


Now this same PCHPL Haridwar Uttarakhand is a contract manufacturer for M/s La Renon Healthcare pvt ltd which market’s, Doctor Prescribed Branded Critizyme, Cirrosam®400, Tamgress™, Sitahenz®-50/100 mgs.

Refer below images of Sitahenz® Phosphate Tablet I.P 100 mgs. This costs Rs 148/10 Tabs M.R.P whereas PMBI P/G Sitagliptin Phosphate I.P 100 mgs costs Rs 100/10 Tabs. Both made by PCHPL Haridwar Uttarakhand.

I wish to add that Sitagliptin molecule was formulated,invented,discovered by Merck & Co Inc and till 31–07–2022 was product patented,in India, sold as Genuine Branded JANUVIA® of Merck & Co Inc & Istavel® by Sun Pharma who is a licensee of Merck & Co Inc. JANUVIA® costs ₹ 270/7 Tablets of 100 mgs each.Istavel®100 mgs ₹ 91/7 Tablets M.R.P. 

Now that P/P has expired, lesser priced indian, branded generics like Sitahenz®I.P are available. 

The biggest shock was when a Original Branded, Innovator, Molecule Discovery, Product Patented, British Company, GSK becomes a marketing company in India selling Rosutec-10 made by Hetero Pharma Labs-3 Village Himchal Pradesh at a higher price as compared to B/G available in PMBJAUSHK. Same with Ceftum 500 Tablets made by Nectar Life Sciences Ltd in Himachal Pradesh marketed by GSK.


 
GSK Ceftum 500mgs m.r.p ₹ 474/4 Tabs Made on Jan 2023. PMBI P/G Drug Code # 79,Generic Name Cefuroxime Axetil I.P 500mgs ₹142/10 Tabs,possibly made by Nectar Life Sciences Ltd.
 
Even High cost medicines like CIRROSAM®400, RAPILIF®D8 New are made by 3rd Party makers in Himachal Pradesh & Tamil Nadu for Marketing Companies M/s La Renon Healthcare Pvt Ltd and IPCA Labs Ltd.

It is possible, that all P/B, B/G, P/G could be made in hilly states Villages of Uttarakhand, Himachal Pradesh, Jammu & Kashmir but marketed under different brand names M.R.P Net Prices. 

The one good thing about lesser know, lesser cost, branded, pure generic companies, is that all have a website, company + GST No, product details, manufacturing address, contact no, medicines search based upon salt, therapy, brand names on their websites.

In reality, there is no difference, between doctor prescribed branded, unknown branded, as both are generics, except that P/B like Strocit®Plus, Cirrosam®400, SitaHenz®100, Epilive®500, Lacoset-50, Lipirose®F10,Tamgress, Rapilif®D8, will be available only in open market.

Whereas the same salt composition, formulation, molecule, api, branded or pure generics, Citinol-PR, Citicoz NS+, Levetram-500, Lacosiez-50,Rosuvat-F, Silodolix-D, 'll be available in PMBJAUSHK at 60-80% discount on M.R.P.

Even in open market, medical shops, there are two competing brands available, of the same, salt composition,Silodosin 8 Mgs+Dutasteride 0.50 mgs for BPH, like Prostagard D8, by Aristo pharma pvt ltd which costs 218/10 Capsules M.R.P, IPCA Labs made Rapilif®D8 @ ₹ 456/10 capsules MRP.  

On TrueMeds Silodozen D 8/0.5 Mg by Elder Project costs ₹ 116/10 Caps (M.R.P 473) made by Akums Drugs even cheaper than what is available in PMBJAUSHK.

In certain nutritional supplements (Where trade margins are very high for all in the chain) Coenzyme Q10, L-carnitine, Piperine, Nano-curcumin, Ubidecarenone, Omega-369 fatty acids, cynocobalmin the options in vegetarian tablets are very few like “Pinaka” by Duke's Lab ₹ 429/10.

Whereas in non vegetarian capsules, the same neutraceutical, can be bought in B/G version as "Healamin forte" for ₹ 300/10 Caps(MRP 650/-), Geomax-3G by Leeford Healthcare for ₹ 75/10 Caps(MRP ₹135) from PMBJAUSHK. 

Unfortunately in this category the prices of vegetarian formulations have been kept much higher than Non Veg. Vegetarian options like AFD shield (260/10) by AFD Pharma, Cozyrich Q10 (MRP ₹380/10) by Leeford Healthcare are available online.

Another Bengaluru based company NewTreeSun’s (Substitute Word for Nutrition) is into Pre-Biotic & Pro-Biotic Capsules (Doctor P/B Wonderlac by Duke's Lab) & Ginseng, Multivitamin Minerals, Nutritional health supplements,Liver Detox Milk Thistle, for Pure Vegans + Vegetarians. The M.R.P on these is very high 799-899 for 60/120 Tablets but they are not effective for that high price. OK for Factory Clearance Price of ₹125-249 per Bottle with Free Shipping.

On 27-03-2023 & 03-04-2023 I got Lesser known B/G+P/G from 1/98 Old Rajinder Nagar, Shankar Road, New Delhi-110060 from PMBJAUSHK.

  • Daxaflow 8D for BPH made by Matins Healthcare Haridwar MKTD by Daxia Healthcare Pvt Ltd Vadodara for ₹ 140/10 Caps (at same price of P/G of PMBI) MRP ₹ 280/10.
  •  Rozutin-F by Knoll®Healthcare Pvt Ltd ₹ 60/10 Tabs (MRP ₹ 271/10 Tabs).This is equal to P/B Lipirose®F10 by Mankind Pharma which costs 162/10.
  • Citicoz-NS Plus ₹ 280/10 Tabs (MRP ₹ 665/10) SAG Neurosciences pvt ltd.
  • Citinol PR ₹ 295/10 Tabs (MRP ₹ 830/10) Knoll Healthcare pvt ltd  
  • Citicoz NS Plus and Citinol PR are equal to Doctor Prescribed Branded Medicines Strocit®Plus of Sun Pharma.
  • Lacosiez-50mgs ₹ 45/10 Tabs (MRP ₹ 95/10),SAG Neurosciences pvt ltd.
  • Levetiracetam 500 mgs ₹ 62/10 Tabs PMBI_P/G Made by Pure & Cure healthcare.
  • Levetram 500mgs ₹ 80/10 marketed by Sentosa GEiGY India Labs Ltd made by Admed Pharma Pvt Ltd HPSIDC Baddi Himachal Pradesh.
  •  Amlodipine 5 mgs PMBI_P/G ₹ 5/10 Tabs & Nebivolol 5mgs P/G ₹40/10 Tabs. 
  • B/G Nebivol 5 mgs by Knoll® Healthcare pvt ltd ₹ 45/10 Tabs (MRP ₹ 141/10)
  • PMBI P/G Nebivolol 5 mgs ₹ 40/10 Tabs.
  • PMBI Pure Generics, Levetiracetam I.P 500mgs (Made by Pure & Cure Healthcare Pvt Ltd) ₹ 62/10 Tabs.
New permutations, combinations, dosage adjustments, juggads, rotations, trials, pulse width modulations,with medicines, like driving a WAG-9HH electric loco with fine 3 phase ac wave form, torque, speed, traction control of squirrel cage 6FRA6068, 6FRA7059 AC induction motors,with Regenerative Braking will start from this day with my Father. 

These types of rotations, juggads, experiments, between P/B, B/G, P/G, legacy, modern new formulations, give me great satisfaction, happiness, thrills.

The main test between P/B, B/G, P/G is the effort needed to break a tablet into 1/2 should be the same,the finishing off the tablets should be the same,the tablet must dissolve in stomach,should not get released fully,partially in stool like a Tamarind seed.

From 21-10-2022 To 31-05-2023, I saved 20,000/-between Doctor Prescribed Branded Versus B/G+P/G. But whenever I get 18% or Higher discount on Doctor P/B, I bought & kept it, for long term stock for Rotations spending ₹ 7,083/- extra. Why ?

When my Father suffered Stroke on 30–06–2022 at 0300 AM detected at 0600 AM with Right Hand & Legs Paralysed, I had plain Strocit®500 mgs + Epilive®500mgs off 2014.

I gave him these Tablets & within 1/2 Hour his legs worked, he climbed 32 stairs down,walked till car & till Emergency Ward Bed of SGRH. Then it was Total Paralysis.

Updated:—16–04–2023 Sunday 14:45 Hrs.

I was browsing through TrueMeds website and found that in all Doctor Prescribed Branded Medicines there was 20% Discount on MRP + 5% Additional Discount on First Order above a certain amount.

So I ordered one blister each off Strocit®Plus,Epilive®500,Lacoset-50,Nebicard-5, Lipirose®F10,Rapilif®D8 New to continue the Rotations.

The assistance of Truemeds executive in callback, pursuading me in prescription upload placing the order,doctor call back, to confirm the order, was commendable, superb & world class.The order was shipped within 2 Hours.

Net Final Price with Free Delivery was ₹ 1,435/- on COD. Arrived on 17–04–2023 Monday @ 14:30 Hrs within 24 hours off Ordering as their Warehouse was only 7 Kms from my Home. Box packing was Tamper Proof with Full seals, Tapings & Genuine Medicines in Correct QTY & Quality were there as Ordered.

Same experience with Pharmeasy where I bought Medicines worth 2,915/-.

Updated:24-04-2023 Monday.

On 18-04-2023 & 23-04-2023 I felt vindicated as I got Nebistar®5 of Lupin Ltd both Online & Offline. One was made in December 2022 MRP ₹244.65/15 Tablets & Another ₹222.50/15 Tablets. In these Lupin LTD has shifted the manufacturing from Hetero Labs Himachal Pradesh to it’s own manufacturing unit in Sikkim. It seems there were some Quality Issues with Hetero Labs. But Dilnip-5 is still being manufactured by Hetero Labs Himachal Pradesh as On October 2022.
 

 

Now the most important aspect which is the Quality of Lesser Known Branded generics & Pure Generics as compared to Doctor prescribed Branded after Multiple Raids, Cancellation of Licenses on Hilly States Third Party Contract Pharma manufacturing companies by the Indian Government in April 2023. Some of these had made Pure Generic medicines(even those that I'd bought On 03-04-2023) for PMBI & BPPI sold via PMBJAUSHK, and exported to Foreign Countries.

Having Written all the above & having experienced Very Little, To No Difference between efficacy of Prescribed Branded, Branded Generics, Pure Generics in Brain Stroke Recovery Treatment,Future Seizure,CVA Prevention with my Father, having heard 100+ Hours on YouTube,reading the Books Bottle of Lies & The Truth Pill-The Myth of Drug Regulation in India my Final Advice will be this.

Once you get a Doctor Prescription for any ailment, don’t buy the brand written immediately. Check the Generic Name of the Medicine, Find which company discovered, formulated, patented the medicine and if it is available in India via imports or local manufacturing. Like Amlogard® Viagra® by Pfizer, Systane® Ultra, Genteal® by Alcon, glivec®400, Vymada®100 by Novartis, Januvia® by Merck,  Nexavar® by Bayer and buy such types.

Buy only original Patented, Branded Imported Medicines in Uncontrolled Type 1 & 2 Diabetes,Cancer Brain Stroke Recovery, Seizure Disorder, Epilepsy, High Brake Cylinder, Wagon Brake Feed Pipe Pressure, Coronary, Weak Heart Disease, Kidney,Liver,Pancreatic Failure, Thyroid,Blood Cancer,Eye Lens,Spine,Brain Surgery, recovery Treatment.

The next is Doctor prescribed branded medicines of reputed Indian Generic Companies as written in the beginning. Here also buy those brands which are made and marketed by one company like Sun Pharma, Pfizer,Intas,Eris and prefer those which are manufactured in Tamil Nadu, Kerala, Karnataka, Andhra Pradesh,Telangana, Maharashtra. A.F.A.P avoid Himachal Pradesh, Uttarakhand, J&K, Harayana,Punjab State Medicines as they ‘d be having inferior quality. If you have to buy medicine’s like GSK’s Ceftum 500,Rosutec, better to buy in PMBJAUSHK, and save money.

Most Doctors consider Lesser Known Branded generics,Pure Generics, of PMBI_BPPI as Govt Shop Rice & Wheat, Fit only for Indian Cows treatment, and Humans consuming them as Vrindavan City Cowherds.They joke that such cowherds, who can’t afford themselves, procreate like Rabbits, have money to smoke Classic/Gold Flake Cigarettes,Biddi’s, Drink Chivas Regal Alcohol, Fly Business Class,Wear Branded Garments, Buy I-Phones, but in medicines want cheapest B/G & P/G.

Nazi, Aryan, Auschwitz, Hitlarian, SS Legacy, Super Speciality (SGRH) Doctor’s, consider PMBJAUSHK B/G & P/G medicines as substandard, US-FDA export rejects, due to Falsified Data, sold @ cost price, to recupp losses, outrightly reject, condemn the entire PMBJAUSHK Scheme, envisaged, for quick gains for a few 10th Rate Pharma makers, vested interests,in Govt, through corruption. Such medicines, will never be stocked in SS Hospitals like SGRH, BLK-Max,Central Delhi.

This view is justified as many generic medicines in the past have failed quality tests and drug maker’s like Mascot Health Series Pvt Ltd, Zee Labs, New Delhi, have been debarred_black listed by PMBI_BPPI.

Whereas what the SS Doctors, prescribe, is Kohinoor/Lal Quila/Daawat Basmati Rice costing  500/Kgs. This is because they know which branded medicine works, for which disease, what is it’s quality,efficacy,as they see patients recovering daily.

There have been cases, where patients, by themselves switched from, Doctor Prescribed Branded, to Unknown Branded Generics, Pure Generics, off 3rd rate pharma companies, during COVID-19 lockdowns, due to financial constraints, which raised their B.P, Blood Glucose,Thyroid, Epilepsy Relapsed, Black out-Seizure happened and Once they returned back to Doctor Prescribed Branded all was normal.

Don't do Gobar_Ganesh experiments between Branded, Prescribed Branded, B/G, P/G. It’ll be a penny wise, pound foolish approach & may lead you to the Hospital, spending in Lakhs, unless you are daily monitoring your Blood Glucose,Thyroid, Brake Cylinder,Feed Pipe Pressure at Home/Office with your own Medical Kits to test the efficacy of B/G & P/G Medicines.

In very narrow therapeutic ailments like Thyroid, High B.P, Heart, Insulin Injections,Women’s Reproductive Health, Mental Health (Psychiatry and Neuro-Psychiatry), even changing between Brands can prove Fatal, forget B/G & P/G. Same with any Medicine prescribed after Life Saving,Organ Transplant Surgery.Never try to save cost here.

You can use B/G+P/G on less important medicines like Antibiotics, Anti-Allergy, Anti-Fungals Borderline High Sugar, Borderline High B.P,Dermatology, Multivitamins, NSAID’s, P.P.I, Statin’s, Aspirin, Prostate Medicines, Neutraceuticals by adopting the policy of take 2 Tabs instead off 1 Tab. Similarly adjust the dosage of Doctor Prescribed Branded, Strocit®Plus, Rapilif®D8 New to once in 3 days if cost is a major issue.

In my Father's Case as his Brain had recovered from Damage to a large extent after using Doctor Prescribed Branded Medicines, continuing the same, with double dose, was a overkill, compressing him, affecting his Physiotherapy, making him comatose, with Brake Cylinder, Wagon Feed Pipe Pressure dropping sharply to 90/70 increasing his Vertigo Problem. So in such case the use off P/B, B/G, P/G rotations helped in maintaining equilibrium. But there must be a person 24*7 to monitor the patient’s condition like myself.

Cost Savings on Medicines, are only for Academic Interest & has no relevance for me personally. My main interest was in Rotations between 3 Types of Medicines, to test them & write my experience, on the flaws, dark side of Indian Pharma for enlightening others.

Now that my experiments are complete I will buy only Doctor Prescribed Branded Medicines which are made+marketed by One Company in their Own Manufacturing Facilities.

In Doctor Prescribed Medicines inflation is 17.89% p.a. October 2021 Made Nebistar®5 by Lupin Ltd costed 202.40/15 Tablets, August 2022 Made 222.50/15 Tabs,December 2022 Made 244.65/15 Tabs.  

A valid question is raised here, that, if Pfizer Inc USA, which formulated,patented Amlodipine 43 years ago, cannot sell Amlogard®5 for less than ₹ 3.03 per Tablet in India, how & with what Quality it is being sold @ ₹0.50 by PMBI in PMBJAUSHK ? And Amlogard® is not a very known Brand in India for Amlodipine.

Pfizer India On 19-May-2023 suffered serious Quality issues on it’s Life Saving Antibiotic Injections, Zosyn, Magnex, Magzex, Magnamycin made by it’s contract maker Astral Steritech and issued a voluntary recall/Stop Usage to Indian Doctors,Hospitals.

On True_Meds, Elder Project is selling Sildozen 8+0.50 mgs @ ₹116/10 Capsules for BPH. It is made by Akums Drugs Pharma Haridwar Uttarakhand parent of M/s Pure & Cure Healthcare (which made PMBI P/G Levetiracetam-500 bought on 03-04-2023) has been raided by Government Agencies for Quality Issues in April 2023. No end to this Menace.

Fortunately the PMBI_P/G Levetiracetam I.P 500mgs which I bought for ₹ 62/10 Tabs on 03-April-2023 was made in 2021 and is working @ 70% efficacy. Levetram-500 (Maker:Admed Pharma)Mktd By:Sentosa GeiGy India Labs Ltd, Citicoz NS Plus (Maker:Logos Pharma) Lacosiez-50 (Maker:Algen Health Care Ltd)Mktd By:SAG Neurosciences,Citinol PR(Maker:Vidhyasha Pharma)Mktd By:Knoll® Healthcare Pvt Ltd worked @ 80% efficacy.

Dated:27-April-2023 Thursday To 22-May-2023 Wednesday.

 On 27-April-2023, I took my Father, to The Neuro Doctor after 5 months, who detected slow progress,But I did not disclose the Fact of Generic Medicines. He Stopped Strocit®Plus and Increased Lacosamide Dosage to 100mgs*2 Tabs per Day with another Brand Sizlac of Alkem Health sciences. Plus he pumped in additional dosage of High Priced Multivitamins of Remylin AX,Ginkocer Plus made by Eris Life Sciences Ltd. Epilive® of Lupin @ 250+500mgs per day along with Lipirose®F10,Tamgress™ 0.4 mgs, LCD-110,Ecospirin-75 mgs was contd for 2 Months.

It is not that Earlier November 2022-April 2023,Prescribed Branded, B/G, P/G are not working, but my father has developed a fatalist, negative, grasshopper,nihilistic attitude, disgust, apathy, mental tiredness, fatigue, lost hope off recovery in life.

He see’s some miracle, chinese accupuncture quacks on T.V, imagines that they only can cure him, which creates mental blocks, medicine efficacy is nullified.

As I’d the PMBJAUSHK Medicines, I exhausted the Stock of B/G Citcoz NS Plus, Citinol-PR,Lacosiez-50,Rosuvat-F, Temsunir_Temsuvell 0.4,Levetram-500, PMBI_P/G Levetiracetam I.P 500mgs, Rabeprazole 20mgs, Pantoprazole 40mgs, Ginseng Multivitamins by 22-05-2023. 
 
But one thing was commendable,these medicines never made my Father Comatose or compressed him, nor did he suffer any seizure or blackout from 26-11-2023 To 22-05-2023.They helped maintain balance & worked OK, for their low cost.
 
Daxaflow 8D,Temsunir 0.4mgs, Temsuvell 0.4mgs, for BPH worked flawlessly equal to Doctor Prescribed Branded IPCA Labs Rapilif®D8 New & B/G Aristo Pharma’s Prostagard D8.This could be tested after taking the medicine and immediate Volume off Urine Discharge by the patient after 1 Hour.

Dated:23-May-2023 Tuesday.

After this I Restored U Boat-571 Full Hydraulics, to Doctor prescribed branded medicines, Lupin’s Epilive® 250/500mgs,Sun Pharma’s Levipil 250/500mgs,Lacoset-50/100mgs, Strocit®Plus, Alkem’s Sizlac-100, Ginkocer Plus, Remylin AX, Lipirose®F10, Rapilif®D8 New.
 
Same with Mother’s B.P Medicines to Lupin’s Nebistar®5,Dilnip 5 & Pfizer’s Amlogard®5. I bought medicines from Local Offline Shop @ 18% Discount for the Next 4 Months, some at Year 2021 rate.
 
The moment my Father commenced Lupin’s Epilive® 250/500mgs the compressing and comatose problem has resurfaced.
 
But now no going back to B/G & P/G of PMBJAUSHK even for Pantoprazole 40mgs. I have purchased Doctor Prescribed Branded PAN-40 of Alkem Health Sciences @ ₹132/15 Tablets (MRP ₹ 155/15) Over PMBJAUSHK_B/G Panpazole 40 of Aishwarya Healthcare Pvt Ltd which Costs ₹ 40/15 Tabs (M.R.P ₹ 169/15 Tabs) & Pure Generic of PMBI ₹12.10/10 Tabs.
 
Jai Shree Krishna Aum Brahman. 
 
Swami Aniruddha
 
     
 


 





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